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The first patent, No. 9,809,623, covers methods of treating inflammatory bowel diseases (IBD) with PTG-100, an orally stable alpha-4-beta-7 integrin peptide inhibitor. PTG-100 was discovered using Protagonist's proprietary technology platform and is currently in Phase 2b testing in patients with moderate-to-severe, active ulcerative colitis. The new patent adds to previously granted U.S. patents No. 9,273,093 and 9,518,091, which also provide protection for the company's alpha-4-beta-7 integrin peptide inhibitors, including PTG-100.
The second patent, No. 9,822,157, covers peptide analogues of hepcidin, including PTG-300, and related pharmaceutical compositions. PTG-300, the company's lead peptide hepcidin mimetic, recently completed a Phase 1 clinical study in healthy volunteers. Protagonist plans to initiate Phase 2 trials of PTG-300 in patients with beta-thalassemia and myelodysplastic syndrome during 2018.
"These new patents further strengthen the long-term intellectual property protection for these clinical-stage assets, both of which have emerged from our innovative peptide technology platform," said
PTG-100, a potential first-in-class oral peptide alpha-4-beta-7 integrin antagonist, is currently in a global Phase 2B clinical trial for the treatment of moderate-to-severe ulcerative colitis. PTG-200, a potential first-in-class oral Interleukin-23 receptor antagonist in development for the treatment of IBD, initially Crohn's disease, is currently being studied in a Phase 1 clinical trial. Protagonist has entered into a worldwide agreement with
In addition to PTG-100 and PTG-200, the company is developing an injectable hepcidin mimetic, PTG-300, for the potential treatment of anemia in iron overload disorders, including rare diseases such as beta-thalassemia and myelodysplastic syndromes. PTG-300 recently completed a Phase 1 clinical trial.
Protagonist is headquartered in
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